Role of Modifier Genes in Idiopathic Cardiomyopathies

نویسندگان

  • Madhu Khullar
  • Ajay Bahl
چکیده

Cardiomyopathies are chronic diseases of heart muscle, in which the muscle is abnormally enlarged, thickened, and/or stiffened (1). According to American Heart Association, “Cardiomyopathies are a heterogeneous group of diseases of the myocardium associated with mechanical and/or electrical dysfunction that usually (but not invariably) exhibit inappropriate ventricular hypertrophy or dilatation and are due to a variety of causes that frequently are genetic. Cardiomyopathies either are confined to the heart or are part of generalized systemic disorders, often leading to cardiovascular death or progressive heart failure related disability” (1). Within this broad definition, WHO (1995) and International Society & Federation of Cardiology has classified cardiomyopathies into four types:  Dilated cardiomyopathy (DCM)  Hypertrophic cardiomyopathy (HCM)  Restricted cardiomyopathy (RCM)  Arrhythmogenic right Ventricular cardiomyopathy

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تاریخ انتشار 2012